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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
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| "My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY |
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Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009. It is always better to use simple English when writing descriptive articles, like this one on cherry juice and gout. It is the layman who may read such articles, and if he can't understand it, what is the point of writing it?
It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial. We have used clear and concise words in this article on cherry juice and gout to avoid any misunderstandings and confusions that can be caused due to difficult words.
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
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People Said About Goutezol Gout Treatment
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HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove. Keeping to the point is very important when writing. So we have to stuck to cherry juice and gout, and have not wandered much from it to enhance understanding.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. We have used a mixture of seriousness and jokes in this composition on cherry juice and gout. This is to liven the mood when reading about cherry juice and gout.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
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Learn More about Natural Gout Remedy
Gout is a very painful health problem that usually effects the big toe. It can, however, effect other joints such as the fingers, knees, etc. It is caused by the build up of crystals of uric acid depositing in the tissues of the body. When the body is unable to break down uric acid it accumulates causing inflammation of the joint(s). Uric acid is also known for causing kidney stones.
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When suffering from the disorder, the pain relief gout remedies can offer can become one of the most important goals in your life. Though exercise is considered to be a great preventative for gout, it is neither a comfortable nor a practical method for relieving the discomfort that is felt at the time of an attack. Many people are lead to believe, therefore, that medications are their only...
Because there is no traditional cure for gout, gout alternative treatments have been the newest rave with this type of arthritis. Millions of people suffer from this painful type of arthritis that is contributed to high levels of uric acid between the joints. And these gout remedies work because they naturally lower the levels of uric acid by flushing it out of the body.
Though uric acid...
Shhh! You can treat gout naturally, forget about the pain, save hundreds of dollars and do this all with NO doctor! These gout remedy tips have literally been costing pharmaceutical companies millions of dollars because the public is beginning to find out that pain killers and steroids are not the only treatment for gout!
In fact, by...
Although there are many factors that can contribute to a build up of uric acid within your system, alcohol consumption appears to be a leading factor in gout development. However, this doesn't mean that people who drink alcohol modestly on a regular basis will develop gout. Furthermore, research has discovered that different types of alcoholic beverages have different impacts on uric acid...
oatmeal and uric acid | kidney stones in cats | low purine vegetables | cherry juice and gout | kidney stone medicine | special diet for gout |
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